|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
SIAH1 inactivation correlates with tumor progression in hepatocellular carcinomas.
|
12557228 |
2003 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
We have reported that SIAH1 is down-regulated and associated with apoptosis and invasion in human breast cancer.
|
25851994 |
2016 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Here, we re-evaluated the effects of SIAH1 and SIAH2 depletion in breast cancer cell lines, focusing on migration and invasion.
|
26654769 |
2015 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Siah1 or Siah1L significantly reduced invasion ability of SKBR3 and suppressed Tcf/Lef factor activity.
|
20682032 |
2010 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
These findings suggest that Siah1 plays important roles in the migration and invasion of human glioma cells under hypoxia, which may provide some guidance for the targeted therapy of human glioma based on the interference of the Siah1-PHD3-HIF-1α signaling pathway.
|
25572001 |
2015 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results reveal that miR-107 is an upstream regulator for SIAH1 down-regulation in human breast cancer cells and miR-107 provides a potential effective target for the treatment of TNBC.
|
25851994 |
2016 |
|
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results reveal that miR-107 is an upstream regulator for SIAH1 down-regulation in human breast cancer cells and miR-107 provides a potential effective target for the treatment of TNBC.
|
25851994 |
2016 |
|
Stomach Neoplasms
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Inactivating mutations of the Siah-1 gene in gastric cancer.
|
15467739 |
2004 |
|
Stomach Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that inactivating mutations of the Siah-1 may contribute to the development of gastric cancer through beta-catenin stabilization and apoptosis block.
|
15467739 |
2004 |
|
Stomach Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, this work delineated the role of Siah1 in increasing invasiveness of H. pylori-infected GCCs.
|
28481365 |
2017 |
|
Steatohepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Together, our data uncover a novel epigenetic pathway that may contribute to the regulation of SIAH1 expression and the pathogenesis of steatosis.
|
28843785 |
2017 |
|
Squamous cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Siah-1 is associated with expression of hypoxia-inducible factor-1α in oral squamous cell carcinoma.
|
27616748 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, in 16 cases of the lymph node metastasis-positive category (N1-3), the mean Siah-1 expression score was significantly higher than that in 42 cases of the lymph node metastasis-negative category (N0, p=0.001).
|
27616748 |
2017 |
|
Sebaceous adenocarcinoma of eyelid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, several parameters distinguish MGC from BCC samples: (i) the mRNA level of the shelterin subunits decreased in MGC but it increased in BCC; (ii) P53 was more highly mutated in MGC; (iii) Siah1 mRNA was over-expressed in BCC; (iv) BCC samples contain a higher level of senescent cells; (v) Ki-67 and Bcl2 expression were lower in BCC.
|
26437300 |
2016 |
|
Reoviridae Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The E3 Ubiquitin Ligase Siah-1 Suppresses Avian Reovirus Infection by Targeting p10 for Degradation.
|
29321312 |
2018 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We find that SIAH1 and SIAH2 are expressed in all human epithelial cell lines examined thus far, while SIAH3 is only expressed in a limited subset of cancer cell lines.
|
28784114 |
2017 |
|
Parkinson Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that Siah-1-mediated alpha-synuclein ubiquitination may play a critical role in Lewy body formation and PD pathogenesis.
|
18065497 |
2008 |
|
Parkinson Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that lncRNA small nucleolar RNA host gene 1 (SNHG1) and seven in absentia homolog 1 (SIAH1) were upregulated, but microRNA-15b-5p (miR-15b-5p) was downregulated in SH-SY5Y cells pretreated with MPP+, as well as in MPTP-induced mouse model of PD.
|
29217406 |
2018 |
|
Parkinson Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We therefore conclude that genetic alterations of SIAH-1 do not significantly contribute to the pathogenesis of PD.
|
16752048 |
2006 |
|
Parkinson Disease
|
0.030 |
Biomarker
|
disease |
LHGDN |
Our findings suggest that Siah-1-mediated alpha-synuclein ubiquitination may play a critical role in Lewy body formation and PD pathogenesis.
|
18065497 |
2008 |
|
Pancreatic Neoplasm
|
0.010 |
Biomarker
|
disease |
LHGDN |
Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue.
|
18089810 |
2007 |
|
Oropharyngeal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To determine whether Siah-1 is important for the proteasomal degradation of beta-catenin in HPV16-positive oropharyngeal cancer cells, we introduced a Siah-1 expression vector into 147T and 090 cells and found substantial reduction of endogenous beta-catenin in these cells.
|
20215420 |
2010 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells.
|
29217406 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, Siah-1 appears to be correlated with clinicopathological data, particularly tumor size.
|
27616748 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We report here, that Siah1 was expressed highly in human glioma tissues compared with its expression in normal brain tissues and was correlated with advanced tumor status and stage.
|
25572001 |
2015 |